N-Acetyl Epitalon Amidate
N-acetylated amide derivative of Epitalon — PubChem
Research Hub — Aggregated Studies
MedTech Research Group aggregates published research from peer-reviewed journals, clinical trials, and academic institutions. We do not conduct original research. All studies cited below are the work of their respective authors and institutions. Sources are linked for verification.
This product is designated FOR RESEARCH USE ONLY (RUO). These compounds have not been approved or cleared under 21 U.S.C. § 505 and have not been evaluated by the FDA for safety, efficacy, or labeling for clinical, diagnostic, or therapeutic use in humans or animals.
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Purchaser Restrictions
- Purchaser must be a qualified researcher at an accredited institution or licensed research facility
- This product may not be sold or redistributed to individual consumers, wellness clinics, health food stores, or retail establishments
- Not intended for human or animal consumption, diagnostic use, or therapeutic application
- Institutional affiliation and research purpose will be verified prior to order fulfillment
Distribution is limited to qualified research use in compliance with applicable federal and state law. These products bear the "For Research Use Only" designation per FDA labeling requirements (minimum 10 pt. font). Ref: 21 U.S.C. § 505; FD&C Act § 201(p) (unapproved new drug definition).
| Risk Tier | GREEN |
| Category | Longevity / Anti-Aging |
| Subcategory | Enhanced Telomerase Activation |
| Pharmacological Class | Modified Peptide Bioregulator |
| Subclass | N-Acetylated, C-Amidated Tetrapeptide |
| Molecular Type | Modified Synthetic Tetrapeptide (Ac-Ala-Glu-Asp-Gly-NH2) |
| Origin | Synthetic modification of Epitalon with N-terminal acetylation and C-terminal amidation |
| Regulatory Status | Research Use Only |
| Route of Administration | Subcutaneous injection |
| Reconstitution | Lyophilized powder; reconstitute with bacteriostatic water |
| Storage | Refrigerate (2-8°C) |
Description
N-Acetyl Epitalon Amidate is a chemically modified version of Epitalon designed for enhanced pharmacological properties. Two modifications have been made to the base Epitalon tetrapeptide: N-terminal acetylation (addition of an acetyl group to the amino terminus) and C-terminal amidation (replacement of the carboxyl group with an amide group at the carboxy terminus).
These are standard peptide chemistry modifications with well-understood effects. N-terminal acetylation protects the peptide from aminopeptidase degradation (enzymes that cleave amino acids from the N-terminus), while C-terminal amidation protects against carboxypeptidase degradation and can improve receptor binding affinity by reducing the negative charge at the C-terminus. Together, these modifications significantly extend the peptide's half-life in biological fluids, improve its resistance to enzymatic degradation, and may enhance its cellular uptake and bioactivity. The net result is a more potent, longer-lasting version of Epitalon that may require lower doses or less frequent administration to achieve equivalent biological effects.
- All Epitalon warnings and considerations apply
- Modified peptides may have different pharmacokinetic profiles — dosing protocols for unmodified Epitalon may not directly translate
- The higher per-milligram cost ($28.41 for 5mg vs. $19.77 for 10mg of standard Epitalon) reflects the enhanced formulation
Published Research
Published Research & Clinical Data
Peer-reviewed studies and clinical trial data related to N-Acetyl Epitalon Amidate
All research below is conducted by independent institutions. MedTech Research Group provides these references for informational purposes only.
Research citations are being compiled for this compound.
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